Fri Mar 28 2025

82 articles - From Friday Mar 21 2025 to Friday Mar 28 2025

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Clin Gastroenterol Hepatol

AGA Clinical Practice Update on Sclerosing Mesenteritis: Commentary.

Methods This Clinical Practice Update expert commentary was commissioned and approved by the AGA Institute Clinical Practice Updates Committee and the AGA Governing Board to provide timely guidance on a topic of high clinical importance to the AGA membership, and underwent internal peer review by the Clinical Practice Updates Committee and external peer review through standard procedures of Clinical Gastroenterology and Hepatology. This expert commentary incorporates important and recently published studies in this field, and it reflects the experiences of the authors who are gastroenterologists with expertise in this topic.

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Endoscopy

Endoscopic Sustainability PrimAry Reporting Essentials (E-SPARE): European Society of Gastrointestinal Endoscopy (ESGE) Position Statement.

However, there are currently no guidelines or frameworks which provide specifically for the reporting of endoscopy sustainability studies, and a variety of metrics and assessment tools have been employed in the literature. To improve the clarity, transparency, and quality of reporting, the European Society of Gastrointestinal Endoscopy (ESGE) has developed a reporting framework for the community of researchers interested in conducting studies on sustainable GI endoscopy.

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Management of epithelial precancerous conditions and early neoplasia of the stomach (MAPS III): European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter and Microbiota Study Group (EHMSG) and European Society of Pathology (ESP) Guideline update 2025.

At a population level, the European Society of Gastrointestinal Endoscopy (ESGE), the European eradication for patients with precancerous conditions and after endoscopic or surgical therapy. ESGE/EHMSG/ESP recommend that patients should be advised to stop smoking and low-dose daily aspirin use may be considered for the prevention of gastric cancer in selected individuals with high risk for cardiovascular events.

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Gastroenterology

AGA Living Clinical Practice Guideline on Computer-Aided Detection-Assisted Colonoscopy.

This guideline highlights the close tradeoff between desirable and undesirable effects and the limitations in the current evidence to support a recommendation. The panel acknowledged the potential for CADe to continually improve as an iterative artificial intelligence application. Ongoing publications providing evidence for critical outcomes will help inform a future recommendation.

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Gastrointest Endosc

Establishing Standards of Practice for Endoscopic Sleeve Gastroplasty: A Global Expert Consensus using a Modified Delphi Method.

Key procedural elements with highest consensus included starting at the incisura, using at least six sutures, and avoiding the fundus. This expert consensus provides step-by-step guidance for safe and effective performance of ESG.

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Meta-analysis

meta-analyses and systematic reviews

Aliment Pharmacol Ther

Meta-Analysis: Pregnancies With Inflammatory Bowel Disease Complicated by Intrahepatic Cholestasis of Pregnancy.

Patients with IBD have a higher risk of ICP compared to the general population. Thiopurine exposure in patients with IBD is associated with an increased risk of ICP. Clinicians should monitor pregnant patients with IBD exposed to thiopurines for symptoms of ICP.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther

Clinical Trial: Effect of Abdominal Vibration Combined With Walking Exercise Programme on Bowel Preparation in Older Patients With Constipation.

This provides empirical evidence suggesting that AVCWE may help improve bowel preparation quality among older patients with constipation. Chinese Clinical Trial Registry, Number: ChiCTR2300067667.

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Am J Gastroenterol

Complications of ileus and bowel obstruction during pregnancy in women who have had surgery for IBD: A population-based study.

There is a significant risk of ileus/bowel obstruction during pregnancy in women who had IBD surgery prior to pregnancy.

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PREVENTION OF ALCOHOL-ASSOCIATED LIVER DISEASE.

In this article, we will review the emerging evidence for public health policies (minimum unit price of alcohol, limiting or banning alcohol advertising), aiming to reduce the availability of alcohol at the population level (primary prevention), preventing ALD especially advanced form of cirrhosis in at risk individuals (secondary prevention), and improving liver outcomes and long-term survival in patients with advanced ALD of cirrhosis and / or alcohol-associated hepatitis (tertiary prevention). We will highlight the critical role of clinicians in promoting the public health policies, widespread screening for AUD and for ALD, and integrating liver with addiction care for patients with ALD.

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Pregnancy tTG-IgA seropositivity and maternal and infant health in the Child Health and Development Studies.

tTG-IgA seropositivity was associated with the presence of two or more markers of celiac comorbidity. Offspring exposed to maternal seropositivity had poorer fetal growth and lower infant weight gain. Findings support the potential beneficial role of tTG-IgA screening during pregnancy, both for the pregnant woman and exposed offspring.

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Endoscopy

Colorectal cancer incidence following a negative colonoscopy in fecal immunochemical test-based screening: a nationwide cohort study after 8 years of screening in Denmark.

However, the lower risk might not justify 8 years of quarantine, especially for women and younger age groups. Individualized screening is warranted and transfer of evidence from non-FIT screening should be done carefully.

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Recurrences after piecemeal endoscopic mucosal resection of 10-20mm non-pedunculated colorectal polyps: a multicenter cohort study.

This real-world study found a substantial recurrence rate at ESC following pEMR of 10-20mm NPCPs. ESC scar identification was moderate but improved with tattoo placement. Although early surveillance could be considered to avoid missing recurrences, the small recurrence size and absence of high-grade dysplasia suggest that modestly extending the interval beyond that of our study may still allow timely detection of recurrences and metachronous lesions.

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Gastroenterology

Clinical Implementation of Artificial Intelligence in Gastroenterology: Current Landscape, Regulatory Challenges, and Ethical Issues.

Ethical and medicolegal concerns exist relating to data governance, patient harm, liability and bias. This review provides an overview for AI clinical implementation in gastroenterology and offers potential solutions to current barriers.

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Efficacy and Safety of Guselkumab Subcutaneous Induction and Maintenance in Participants with Moderately to Severely Active Crohn's Disease: Results from the Phase 3 GRAVITI Study.

Subcutaneous guselkumab for both induction and maintenance was efficacious in treating participants with moderately to severely active CD. Safety findings were consistent with those of guselkumab in approved indications, including ulcerative colitis.

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From "Burnt-Out" to "Burning-Out": Capturing Liver Fat Loss in Patients with Advanced Metabolic Dysfunction-Associated Steatotic Liver Disease from A Dynamic Perspective.

Continuous hepatic fat loss accompanied by fibrosis progression, referred to as "burning-out", was observed in advanced MASLD and associated with high rates of all-cause mortality, LREs and hepatic decompensation.

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Machine learning and artificial intelligence in the multi-omics approach to gut microbiota.

Such tools show potential for clinical implementation, including the discovery of microbial biomarkers for disease classification or prediction, the prediction of response to specific treatments, the fine-tuning of microbiome-modulating therapies. Here we discuss the state of the art, potential, and limits, of artificial intelligence and machine learning in the multi-omics approach to gut microbiome.

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Perforin Generated by CD8+ T Cells Exacerbates IBD-Induced Depression by Promoting CXCL9 Production in Intestinal Epithelial Cells.

Neutralizing CXCL9 in vivo alleviated depression but had no effect on colitis in mice. Perforin generated by colonic CD8+ T cells promotes intestinal epithelial cell CXCL9 production, which leads to neuronal ER stress in hippocampus and induces depression in IBD.

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Systemic identification of functionally conserved lncRNA metabolic regulators in human and mouse livers.

Our study supports that fcLMRs represent a novel and prevalent biological phenomenon, and deep phenotyping of genetic mLMR mouse models constitutes a powerful approach to understand the pathophysiological role of lncRNAs in the human liver.

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The efficacy of texture and color enhancement imaging (TXI) observation in the detection of colorectal lesions: a multicenter, randomized controlled trial (deTXIon study).

This study did not demonstrate the superiority of TXI over WLI in detecting neoplastic lesions. However, TXI may be effective in detecting flat polyps.

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Gastrointest Endosc

EUS fine-needle biopsy of solid pancreatic masses with and without rapid on-site evaluation for commercial next generation genomic profiling.

However, compared with FNB without ROSE, FNB with ROSE required more than double the procedure time (mean (SD): 21.1 (10) vs 49.7 (20.6) min, p<0.001) and significantly higher number of median needle passes (3 (IQR 2-3) vs 4 (IQR 3-4), p<0.001). While EUS-FNB with ROSE did not have significantly different adequacy for commercial genomic analysis compared to EUS without ROSE, it required significantly more procedure time and needle passes.

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Frequency and Predictors of Delayed Clearance of Prophylactic Pancreatic Stents following ERCP.

Prophylactic PS was cleared within 4 weeks in only half of the patients following ERCP. In addition to primarily endoscopist-driven factors, biliary stent placement was associated with delayed clearance of prophylactic PS.

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Randomized Trial Comparing the Franseen Needle Versus Two Types of Sharpened-Tip Three-Prong Needles in Endoscopic Ultrasound-Guided Tissue Acquisition from Solid Pancreatic Lesions.

The conventional FNB needle demonstrated a higher tissue-collection rate but did not surpass the noninferiority margin that was set in this study, with no significant differences in the histological diagnostic performance or the tissue volume between the needles. The superior puncture performance of the novel needles suggests their particular benefit in challenging cases or for less experienced endoscopists.

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The Burden and Cost of Post-ERCP Pancreatitis Among Commercially Insured People Undergoing ERCP.

The population-level cost of post-ERCP pancreatitis ranged from $85,833,757 to 432,648,810 across a range of reported estimates for post-ERCP pancreatitis and annual ERCP volume in the US. Post-ERCP pancreatitis is relatively uncommon, occurring in 5-6% of individuals, but results in substantial financial burden.

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Gut

Diagnostic efficacy of an extracellular vesicle-derived lncRNA-based liquid biopsy signature for the early detection of early-onset gastric cancer.

The newly developed EV-lncRNA signature effectively identified EOGC patients at a resectable stage with enhanced precision, thereby improving the prognosis of patients who would have otherwise missed the curative treatment window.

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Dietary whey protein protects against Crohn's disease by orchestrating cross-kingdom interaction between the gut phageome and bacteriome.

Importantly, we uncovered a beneficial dietary WP, a keystone phage AkkZT003P, and a probiotic S. thermophilus that can be used in CD management in the future.

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Endothelial-like cancer-associated fibroblasts facilitate pancreatic cancer metastasis via vasculogenic mimicry and paracrine signalling.

FAPα+CD144+endoCAFs can promote metastasis of PDAC via undertaking VM and paracrine through activation of the CD144-β-catenin-STAT3 signalling axis. CAF-targeting siRNA delivery nanosystem can inhibit tumour progression by precisely targeting FAPα+CD144+endoCAFs.

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Longitudinal paired liver biopsies and transcriptome profiling in alcohol-associated hepatitis reveal dynamic changes in cellular senescence.

Our in vitro model revealed that ethanol directly induces senescence and was dependent on ethanol metabolism. Our results suggest a possible pathogenic role for senescence in AH and indicate cellular senescence as a potential therapeutic target in early ALD to limit AH severity.

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Rectal diclofenac versus indomethacin for prevention of post-ERCP pancreatitis (DIPPP): a multicentre, double-blind, randomised, controlled trial.

Pre-procedure 100 mg rectal diclofenac was not superior to the same dose of rectal indomethacin regarding preventing PEP. These findings supported current clinical practice guidelines of 100 mg indomethacin or diclofenac for PEP prophylaxis in patients without contraindications.

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Hepatology

Associations between metabolic syndrome and cholangiocarcinoma risk: A large-scale population-based cohort study.

The positive association between metabolic syndrome and cholangiocarcinoma risk suggests that managing metabolic risk factors might reduce the occurrence of both intra- and extra-hepatic cholangiocarcinoma.

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Deep learning analysis of magnetic resonance imaging accurately detects early-stage perihilar cholangiocarcinoma in patients with primary sclerosing cholangitis.

The 3D DenseNet-121 MRI model effectively detects early-stage pCCA in PSC patients. Compared to expert radiologists, the model missed fewer cases of cancer.

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Early screening, diagnosis and recurrence monitoring of hepatocellular carcinoma in chronic hepatitis B patients based on serum N-glycomics analysis: A cohort study.

N-glycomics models can effectively predict the occurrence and recurrence of HCC to improving the efficiency of clinical decision-making and promoting the precision treatment of HCC.

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Higher level of Hepatitis B Surface antigen associated with delayed development of hepatocellular carcinoma in immune-tolerant patients.

Predictive roles of HBV DNA and HBsAg levels in HCC development differ between HBeAg-negative and HBeAg-positive patients. Particularly, among immune-tolerant patients, HBsAg levels ≥10,000 IU/mL showed delayed development of HCC, suggesting HBsAg as a biomarker to define genuine immune-tolerant patients.

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Neutrophil serine proteases NE and PR3 controlled by the miR-223/STAT3 axis potentiate MASH and liver fibrosis.

Our findings reveal that NE and PR3 are key factors triggering liver inflammation to potentiate the development of MASH and liver fibrosis, offering insight into the development of new therapeutic approaches that target NE and PR3.

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Proton density fat fraction for diagnosis of metabolic dysfunction associated steatotic liver disease.

PDFF was the most accurate single classifier for diagnosing MASLD, MASH, and fibrotic MASH. The most accurate multivariable classification models for MASLD, MASH, and fibrotic MASH included PDFF, demonstrating the central importance of PDFF for noninvasive assessment of the MASLD spectrum.

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The Liver Transplant Comorbidity Index (LTCI) : A composite index of ambulatory Pre-LT factors to identify patients at increased risk of Post-LT Mortality.

The LTCI, comprising 5 pre-transplant clinical parameters, effectively identifies patients at increased risk of post-transplant mortality. By integrating frailty in the context of other co-morbidities, the LTCI can help providers better weigh the relative transplant risks and benefits and standardize selection of transplant candidates.

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J Hepatol

Effect of albumin treatment duration on response rates and outcomes in patients with cirrhosis and acute kidney injury.

A substantial proportion of patients requires 48 hours to respond to albumin treatment. Shortening time of albumin therapy may lead to overtreatment with terlipressin. Impact and implications This study provides valuable insights into the optimal duration of albumin treatment for patients with cirrhosis and acute kidney injury (AKI), challenging the recent recommendation of shortening the treatment period with albumin. Furthermore, the optimal definition for response to albumin (reduction of at least one AKI stage) has been assessed. The results of this study are highly clinically relevant since shortening albumin therapy may lead to overtreatment with terlipressin, and evidence to support the choice of the definition of response to albumin was lacking. Clinicians can use these findings to predict treatment outcomes better, avoid fluid overload, and improve patient prognosis while also considering the potential risks of early intervention with terlipressin.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Aliment Pharmacol Ther

Editorial: Cumulative Impact of Clinical Disease Activity, Biochemical Activity and Psychological Health on the Natural History of Inflammatory Bowel Disease During 8 Years of Longitudinal Follow-Up.

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Clin Gastroenterol Hepatol

Blue Notes.

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Gastroenterology

Complications of ERCP.

Innovations in stent, hemostasis, and perforation closure technology now allow effective and efficient endoscopic management of several important non-pancreatitis complications. Overall, our ability to prevent and treat ERCP related adverse events has improved substantially, amplifying the importance of a high level of suspicion for, and a thorough understanding of these events.

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Our New President-Lawrence Kim, MD, MBA, AGAF.

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Regulation of Hepatic Stellate Cell Phenotypes in MASH.

This fibrotic process is a key feature of MASH, which can lead to cirrhosis and liver cancer. Understanding the mechanisms of HSC activation and their role in MASH progression is essential for developing targeted therapies to treat and prevent liver fibrosis in affected individuals.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol

Ileal pouch adenocarcinoma in a young patient with newly diagnosed Crohn's-like disease of the pouch.

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Clin Gastroenterol Hepatol

Influence of low-dose acetylsalicylic acid on renal function in patients with liver cirrhosis and ascites.

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Transition of Care in Celiac Disease: A Chance to Advance.

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Endoscopy

A novel technique for gastrostomy tube replacement following post-radiotherapy esophageal atresia: the joint forces of double endoscopy.

Pubmed   Journal   ReadQx   PMC

A step forward for improving the endoscopic diagnosis of autoimmune gastritis.

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An innovative technique for closing a post-endoscopic submucosal dissection ulcer to prevent early dehiscence, the muscle-grasping clip with line pulley securing technique.

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Antegrade bilateral metal stent deployment under endoscopic ultrasound guidance for hepatic hilar obstruction using locking stent technique.

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Diagnosis of massive obscure gastrointestinal bleeding from a Dieulafoy lesion identified by intraoperative enteroscopy.

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Don't waste the chance to see everything at once!

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Endoscopic ultrasound-guided hepaticogastrostomy without tract dilation using a novel ultra-tapered slim-delivery metallic stent.

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Endoscopic ultrasound-guided mucosal dissection to remove an entirely embedded esophageal fishbone.

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Endoscopic ultrasound-guided vascular intervention for isolated gastric varices using the hydrocoil of an electrically detachable system.

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Endoscopy E-Videos - recently published.

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Exposed embolization coils left in situ after embolization of a pseudoaneurysm inside walled-off pancreatic necrosis and subsequent successful direct endoscopic necrosectomy.

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Intraoperative collaboration between surgeons and endoscopists who performed previous endoscopic ultrasound in laparoscopic ultrasound-guided pancreatic tumor enucleation.

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Microcatheter-assisted guidewire manipulation via peroral pancreatoscopy for recanalization of pancreaticojejunostomy obstruction.

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Modified endoscopic hand-suturing without scope reinsertion for an ileocecal defect after endoscopic submucosal dissection.

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Over-the-wire lumen-apposing metal stent for the management of a chronic fistula after one-anastomosis gastric bypass.

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Removing a large pedunculated colonic polyp using a loop anchored with clips at the root.

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Scraping away technique under cholangioscopy using an improved forceps biopsy device for Mirizzi syndrome.

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Successful biliary decompression for multiple biliary obstructions by bridging stenting using the partial stent-in-stent method via endoscopic ultrasound-guided hepaticogastrostomy.

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Transpapillary stenting by the rendezvous technique using a novel device delivery guide sheath via percutaneous transhepatic biliary drainage route for hilar biliary obstruction.

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Underwater compression hemostasis method for active bleeding in underwater endoscopic submucosal dissection.

Pubmed   Journal   ReadQx   PMC

Gastroenterology

A rare cause of rapid progression to intestinal failure.

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Clinical trials for perianal Crohn's disease: A call for a revised approach.

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Deconstructing Diagnostic Upper Endoscopy for the Novice Learner: A Delphi Survey of Gastroenterology Program Directors.

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High-flow nasal cannula oxygen therapy reduces the incidence of hypoxia during deeply sedated endoscopy.

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Rifaximin does not increase the rate of 30-day mortality in patients with cirrhosis and daptomycin in two National US-based cohorts.

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Sweet Tooth? Blame It on Your Dessert Brain!

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Gastrointest Endosc

Success of Different Closure Modalities of Gastro-gastric or Jejunal-gastric Fistulas after Endoscopic Ultrasound-directed Transgastric Intervention.

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Gut

Rectal non-steroidal anti-inflammatory drugs and post-ERCP pancreatitis: it is time for the next chapter in prophylaxis.

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Hepatology

Deciphering the spatial tumor microenvironment in intrahepatic cholangiocarcinoma.

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Letter to the Editor: Primary sclerosing cholangitis and autoimmune hepatitis - distinct or common autoimmune penetrance?

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Letter to the Editor: targeted enteral feeding for malnutrition in liver transplant candidates.

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Reply: Targeted enteral feeding for malnutrition in Liver Transplant candidates.

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J Hepatol

Unpicking the senescence paradox in MASLD-associated HCC.

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Letters&Replies

Letters to the editors and authors’ replies

Aliment Pharmacol Ther

Editorial: Cumulative Impact of Clinical Disease Activity, Biochemical Activity and Psychological Health on the Natural History of Inflammatory Bowel Disease During 8 Years of Longitudinal Follow-Up. Authors' Reply.

Pubmed   Journal   ReadQx 

Letter: Disappearing Microbe, Emerging Disease? Nuancing the Protective Effects of Helicobacter pylori Against Eosinophilic Oesophagitis.

Pubmed   Journal   ReadQx 

Letter: Disappearing Microbe, Emerging Disease? Nuancing the Protective Effects of Helicobacter pylori Against Eosinophilic Oesophagitis. Authors' Reply.

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Gastroenterology

Individual Differences in Gut Microbiota: Reconsidering CP101 Efficacy and the Potential Benefits of Bowel Preparation.

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Gut

Global prevalence of ultra-short coeliac disease (USCD): the first systematic review and meta-analysis.

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